BACKGROUND: Plasma protein alterations may occur in patients with acute myocardial infarction (AMI). In this study, we investigated the plasma proteomics of patients with first-onset AMI to identify a novel diagnostic target for myocardial infarction. METHODS: Using a case-control design, we recruited 6 patients with first-onset AMI and 6 age- and sex-matched healthy controls. Mass spectrometry was used to analyze their plasma proteomics. Additionally, we enrolled 156 patients with AMI and 232 healthy individuals to validate the differentially expressed proteins using ELISA. RESULTS: A total of 58 differentially expressed proteins were identified between the 2 groups ( CONCLUSIONS: TMSB4 holds diagnostic value for first-onset myocardial infarction and may therefore be considered a potential diagnostic marker for infarction. REGISTRATION: URL: https://www.chictr.org.cn/
unique identifier: ChiCTR2300078144.