Objectives: To compare short-term outcomes of stapled to hand-sewn anastomosis of colon to rectum in treatment of colorectal cancer. Method: Retrospective two-arm comparison study. Results: 104 patients with sigmoid and upper rectal cancer were divided into two groups: 50 patients with stapled anastomosis and 54 patients with hand-sewn anastomosis. The average operation time is 120.4 - 141.35 minutes. The time of having postoperative gas is 3.1-3.4 days. The duration of post-operative hospital stay is 7.8 - 8.1days. The rate of anastomotic leak is 2%-1.8%, anastomotic bleeding is 4%-1,8%, anastomotic narrowing is 4%- 1,8%, surgical wound infection 2% - 7.4%. Conclusion: In comparison of stapled and hand-sewn techniques in anastomosis of colon to rectum in treatment of colorectal cancer, the author conclude that there is no difference between the two groups in terms of duration of having post-operative gas, hospitalization stay, and rate of anastomotic leakage. However the operation time in group using stapler is shorter than gnaup with hand sewing. Patients with stapled anastomosis have higher rate of anastomote bleeding, anastomotic nan-owing but lower rate of surgical wound infection than the other group.