Monitoring the neurological complications of chimeric antigen receptor (CAR) T-cell therapy in patients with sensory and physical impairments and non-native-speaking backgrounds using modified immune effector cell-associated encephalopathy (ICE) scores: a case series.

• Tác giả: Cassandra Abbott, Rubina Alpitsis, Shaun Fleming, Shafqat Inam, Christina Kazzi, Katherine Ko, Charles Malpas, Mastura Monif, Terence J O'Brien, Nabil Seery, Ty Simpson, Andrew Spencer, Constantine Tam, Tracie Huey-Lin Tan, Robb Wesselingh, Shu Min Wong, Miriam Wronski
• Ngôn ngữ: eng
• Ký hiệu phân loại: 617.752 Eyeglasses, contact lenses, intraocular lenses
• Thông tin xuất bản: England : BMJ neurology open , 2025
• Bộ sưu tập: NCBI
• ID: 57781

Tóm tắt

BACKGROUND: Immune effector cell-associated neurotoxicity syndrome (ICANS) is a common complication of chimeric antigen receptor (CAR) T-cell therapy. Current practice guidelines recommend the immune effector cell-associated encephalopathy (ICE) score for the assessment and monitoring of ICANS. OBJECTIVE: To demonstrate modifications to ICE score to patients with vision and hearing impairments or who are who are from non-native-speaking backgrounds. METHODS: We discuss five cases and the modifications made to adapt the ICE score to meet patients' needs. RESULTS: Modifications to ICE score was feasible and it assisted with CAR T cell therapy outcome monitoring. DISCUSSION: These cases highlight the need for flexible and patient-tailored strategies and the importance of collaboration between multidisciplinary teams and patients' families/caregivers when monitoring patients for ICANS after CAR T-cell therapy.