Study on extracting and evaluating the effect of the extraction of Mesona chinensis Benth. plant in supporting the treatment of obesity in white mice. The quantitative results showed that the content of Polyphenol and Flavonoid in extraction were 375 mg / g high and 265.6 mg / g, respectively. After 6 weeks, rats that received a extraction dose of flute extract had a significant reduction in body weight. In which, 400mg / kg body weight had the highest volume reduction, decreased 9.04g compared to the pre-treatment time or 13.4%.