Viral vectors: design and delivery for small RNA.

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Tác giả: Suet Lin Chia, Wei Chin Koh, Norazalina Saad, Adelene Ai Lian Song, Khatijah Yusoff

Ngôn ngữ: eng

Ký hiệu phân loại: 251.03 Delivery

Thông tin xuất bản: England : Journal of medical microbiology , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 58015

RNA interference regulates gene expression by selectively silencing target genes through the introduction of small RNA molecules, such as microRNA, small interfering RNA and short hairpin RNA. These molecules offer significant therapeutic potential for diverse human ailments like cancer, viral infections and neurodegenerative disorders. Whilst non-viral vectors like nanoparticles have been extensively explored for delivering these RNAs, viral vectors, with superior specificity and delivery efficiency, remain less studied. This review examines current viral vectors for small RNA delivery, focusing on design strategies and characteristics. It compares the advantages and drawbacks of each vector, aiding readers in selecting the optimal one for small RNA delivery.
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