Heteroresistance in Enterobacter cloacae complex caused by variation in transient gene amplification events.

• Tác giả: Julian Brombach, Yuwen Fang, Marcus Fulde, Fereshteh Ghazisaeedi, Dennis Hanke, Johannes Kupke, Benno Kuropka, Antina Lübke-Becker, Niclas Nordholt, Frank Schreiber, Torsten Semmler, Ulrich K Steiner, Karsten Tedin, Lakshmipriya Thrukonda, Silver A Wolf
• Ngôn ngữ: eng
• Ký hiệu phân loại: 784.190287 General principles, musical forms, instruments
• Thông tin xuất bản: England : npj antimicrobials and resistance , 2025
• Bộ sưu tập: NCBI
• ID: 581510

Tóm tắt

Heteroresistance (HR) in bacteria describes a subpopulational phenomenon of antibiotic resistant cells of a generally susceptible population. Here, we investigated the molecular mechanisms and phenotypic characteristics underlying HR to ceftazidime (CAZ) in a clinical Enterobacter cloacae complex strain (ECC). We identified a plasmid-borne gene duplication-amplification (GDA) event of a region harbouring an ampC gene encoding a β-lactamase bla