Biến tính chitosan với n-butyl acrylate – khả năng kháng khuẩn = Modifying chitosan with n-butyl acrylate

Biến tính chitosan với n-butyl acrylate – khả năng kháng khuẩn = Modifying chitosan with n-butyl acrylate - antibacterial ability

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Tác giả: Ngọc Mai Châu, Thị Thái Hà La

Ngôn ngữ: vie

Ký hiệu phân loại:

Thông tin xuất bản: Tạp chí Phát triển Khoa học & Công nghệ: Khoa học Trái đất và Môi trường, 2018

Mô tả vật lý: tr.12

Bộ sưu tập: NCBI

ID: 581515

Thêm vào giỏ

Polyme có nguồn gốc từ thiên nhiên như Chitosan (CS) là một trong những polymer tự nhiên dồi dào nhất trên thế giới có khả năng kháng khuẩn hiệu quả. Tuy nhiên, CS khá khó khăn trong việc đưa vào ứng dụng bởi vì những tính chất bất lợi của nó.Trong bài báo này, CS được biến tính với n-butyl acrylate (BA) thông qua phản ứng đồng trùng hợp và sử dụng tert-butyl hydroperoxide (TBHP) làm chất khơi mào để thu được sản phẩm có nhiệt độ chuyển thuỷ tinh Tg thấp hơn CS ban đầu và mở rộng phạm vi ứng dụng nhưng vẫn giữ được khả năng kháng khuẩn tuyệt vời. Ảnh hưởng của các thông số đối với quá trình tổng hợp copolymer được nghiên cứu thông qua xác định phần trăm ghép (G%) và hiệu quả ghép (E%). Kết quả cho thấy G% và E% đạt giá trị cao nhất ở 242% và 61% với các điều kiện sau: BA/CS = 4 w/w, TBHP/CS = 5 v/w, [TBHP] = 20 mM, [CS] = 0,75% w/v trong dung dịch acetic acid 0,6% và phản ứng được thực hiện ở 90°C trong 6 giờ. Polymer deriving from nature as Chitosan, which is one of the most abundant natural polymers in the world has effectively antibacterial potentiality. However, chitosan is relatively difficult for applications due to its disadvantageous properties.In this article, modifying chitosan (CS) is the grafting copolymerization using monomer n-butyl acrylate (BA) and tert-butyl hydroperoxide (TBHP) as an initiator. This process purposes to attain product having lower glass transition temperature (Tg) than original chitosan causing a wide range of applications but still keeping the capability of being an excellently antibacterial agent. The effects of parameters on synthesizing copolymer were studied by determining the grafting percentage (G%) and grafting efficiency (E%). The results revealed that the highest G = 242% and E = 61% were obtained at the conditions as following: BA/CS = 4 w/w, TBHP/CS = 5 v/w with [TBHP] = 20mM, [CS] = 0.75% w/v in acetic acid 0.6% and reaction temperature 90°C in 6 hours.

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