Human nasal turbinate stem cells with specific gene signatures (HAS2, CXCL1, KRTAP1-5, GSTT2B, and C4B) attenuate rheumatoid arthritis.

• Tác giả: Se Gwang Jang, Jung Ho Jeon, Min-Jun Kim, Sung Won Kim, Seung-Ki Kwok, Jaeseon Lee, Jung Yeon Lim, Hong Ki Min, Sun Hwa Park, Youngjae Park, Young-Suk Song
• Ngôn ngữ: eng
• Ký hiệu phân loại: 341.4 +Jurisdiction over physical space; human rights
• Thông tin xuất bản: England : Scientific reports , 2025
• Bộ sưu tập: NCBI
• ID: 581521

Tóm tắt

This study aimed to investigate the therapeutic effect of human nasal turbinate-derived stem cells (hNTSCs) on mice with rheumatoid arthritis (RA) and identify hNTSC gene signatures with therapeutic effects on RA. hNTSCs were obtained from 20 healthy controls (HCs) who had undergone nasal turbinate surgery. Collagen-induced arthritis (CIA) mice were used to investigate the therapeutic effects of hNTSCs. The engraftment and migration abilities of hNTSCs were evaluated. CD4