Female mice exhibit resistance to disease progression despite early pathology in a transgenic mouse model inoculated with alpha-synuclein fibrils.

• Tác giả: M Mallar Chakravarty, Esther Del Cid-Pellitero, Gabriel A Devenyi, Thomas M Durcan, Edward A Fon, Daniel Gallino, Wen Luo, Kristie Mar, Vladislav Novikov, Janice Park, Megan Park, Raihaan Patel, Marco A M Prado, Vania F Prado, Rodrigo Sandoval Contreras, Irina Shlaifer, Stephanie Tullo
• Ngôn ngữ: eng
• Ký hiệu phân loại: 939.401 Early history to ca. 1900 B.C.
• Thông tin xuất bản: England : Communications biology , 2025
• Bộ sưu tập: NCBI
• ID: 581536

Tóm tắt

 Despite known sex differences in human synucleinopathies such as Parkinson's disease, the impact of sex on alpha-synuclein pathology in mouse models has been largely overlooked. To address this need, we examine sex differences in whole brain signatures of neurodegeneration due to aSyn toxicity in the M83 mouse model using longitudinal magnetic resonance imaging (MRI
  T1-weighted
  100 μm