IL-6 signaling is critical in the pathogenesis of several autoimmune diseases, including psoriasis and psoriatic arthritis. This study utilized Mendelian randomization (MR) analysis to investigate the genetic associations between IL-6 signaling, soluble IL-6 receptor (sIL-6R) levels, and psoriasis and its arthritis. Additionally, the therapeutic potential of IL-6R inhibitors was evaluated. The study methodology was validated through positive and negative control analysis, with further confirmation of genetic associations via Bayesian factor colocalization analysis. The MR results indicated that upregulation of IL-6 signaling was positively associated with psoriasis (P