PTEN loss drives p53 LOH and immune evasion in a novel urothelial organoid model harboring p53 missense mutations.

• Tác giả: Masakazu Fujimoto, Takayuki Goto, Akihiro Hamada, Narumi Hatano, Ryosuke Ikeuchi, Mayumi Kamada, Yuki Kita, Takashi Kobayashi, Shuhei Koike, Norihiko Masuda, Kaoru Murakami, Kenji Nakamura, Osamu Ogawa, Ryoichi Saito, Toru Sakatani, Takeshi Sano, Hideaki Takada, Yuki Teramoto
• Ngôn ngữ: eng
• Thông tin xuất bản: England : Oncogene , 2025
• Bộ sưu tập: NCBI
• ID: 581565

Tóm tắt

Despite missense mutation accounts for over 60% of p53 alterations while homozygous deletion (HOM) for only 5% or less in advanced bladder cancer cases, most of the previously reported mouse models are deficient of p53. Accordingly, few studies have addressed the mechanisms of missense mutation occurrence and its functional advantage over HOM in bladder cancer development. Organoids derived from Krt5-expressing mouse urothelium (K5-mUrorganoid) demonstrated the crucial role of Pten loss in driving loss of wild-type allele of Trp53 (Trp53