Deglycosylation and truncation in the neuraminidase stalk are functionally equivalent in enhancing the pathogenicity of a high pathogenicity avian influenza virus in chickens.

• Tác giả: Hiromu Arakawa, Hinako Ban, Takahiro Hiono, Takaya Ichikawa, Norikazu Isoda, Hiroyuki Kaji, Daiki Kobayashi, Ayako Ohkawara, Yoshihiro Sakoda
• Ngôn ngữ: eng
• Ký hiệu phân loại: 972.8202 *Central America
• Thông tin xuất bản: United States : Journal of virology , 2025
• Bộ sưu tập: NCBI
• ID: 58160

Tóm tắt

Influenza A viruses with fewer amino acids in the neuraminidase (NA) stalk domain are primarily isolated from chickens rather than wild ducks, indicating that a shortened NA stalk is considered an adaptation marker of avian influenza viruses (AIVs) to chickens. Experimental passages of an H7N7 nonpathogenic AIV (rgVac2-P0) in chickens resulted in a highly pathogenic variant (Vac2-P3L4) with a 34-amino-acid deletion in the NA stalk, encompassing five potential