Dengue fever, dengue hemorrhagic dengue fever and dengue shock syndrome were caused by Dengue mosquito bites. Common signs such as fever and headache, are connected to distinctive medical disorders. From the previous and ongoing studies, it is far unknown what genes or protein signaling pathway mechanism underlies the association between DF, DHF and DSS in Indian context. In our study, the gene expression dataset was retrieved from the GEO database with accession number GSE94892. Here, mRNA sequence analysis done of each DF, DHF and DSS patients from peripheral blood mononuclear cells sample. GEO2R became used to carry out differential gene expression analysis using a dengue data set. Protein-protein interaction networks have been built, gene set GO enrichment and KEGG Pathway enrichment done in SR plot, and cluster analyses have been performed in STRING and MCODE. During this study, we diagnosed 10 hub genes in all 3 condition. The gene set of showed that the ten hub genes diagnosed in each condition constituted the best range of common hub genes discovered beneath all 3 conditions in India. The conclusion of this study can be beneficial for treating DF, DHF and DSS conditions within the context of handling DEV in India.