Chondrosarcoma is a rare malignant tumor of epithelial origin, with fewer than 0.1% of cases affecting the nasal septum. Maxillofacial oncological surgery presents significant challenges, particularly in maxillary reconstruction, often requiring complex rehabilitation. This case report describes the use of point-of-care manufacturing, customized cutting guides, and 3D printing technology for fibular-free flap reconstruction and guided dental implant placement in a 42-year-old male with centrofacial nasal chondrosarcoma. After a bilateral maxillectomy, continuity across the maxillomalar buttress was restored using a fibular-free flap and a patient-specific reconstruction plate. Immediate implant placement and prosthetic loading were performed, supported by the Implant Stability Quotient (ISQ), which provided objective data on implant stability, allowing immediate loading due to high primary stability. The integration of point-of-care manufacturing and ISQ enhances precision in guided surgery, facilitating quicker functional and esthetic rehabilitation, and offering faster recovery and improved quality of life for oncological patients requiring complex maxillofacial reconstruction.