Characteristics associated with death or tracheostomy in infants with bronchopulmonary dysplasia following predominant non-invasive respiratory support.

• Tác giả: Catherine M Avitabile, Nicolas A Bamat, Sara B DeMauro, Xiaoyue Dong, Kathleen Gibbs, Heidi Morris, Megan Reilly, Huayan Zhang
• Ngôn ngữ: eng
• Ký hiệu phân loại: 152.1 Sensory perception
• Thông tin xuất bản: United States : Journal of perinatology : official journal of the California Perinatal Association , 2025
• Bộ sưu tập: NCBI
• ID: 581683

Tóm tắt

 OBJECTIVE: Identify characteristics associated with death or tracheostomy (D/T) in preterm infants with bronchopulmonary dysplasia (BPD) predominantly managed with non-invasive respiratory support prior to 36 weeks postmenstrual age (PMA). STUDY DESIGN: Retrospective cohort study at Children's Hospital of Philadelphia of 134 infants meeting inclusion criteria between 2010 and 2017. Various clinical characteristics were considered as predictor variables of the primary outcome, D/T
  those associated at p <
  0.10 in bivariable logistic regression were evaluated in multivariable models. RESULTS: Twenty-one (16%) infants had D/T. Treatment with pulmonary vasodilators and the presence of pulmonary hypertension (PH) on echocardiogram at 36 weeks PMA were associated with D/T in bivariable analyses. Pulmonary vasodilator use remained statistically significant in adjusted multivariable models. CONCLUSIONS: We identified a strong association between PH and D/T in this cohort. Our findings emphasize the importance of specialized BPD management that includes early identification of PH in this high-risk population.