Age-related decline in total testosterone levels among young men: insights from a large single-center observational study.

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Tác giả: Federico Belladelli, Alessandro Bertini, Luca Boeri, Luigi Candela, Christian Corsini, Alessia D'Arma, Francesco Montorsi, Fausto Negri, Edoardo Pozzi, Massimiliano Raffo, Andrea Salonia, Eugenio Ventimiglia

Ngôn ngữ: eng

Ký hiệu phân loại: 929.81 Awards, orders, decorations

Thông tin xuất bản: England : International journal of impotence research , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 581712

 We aimed to depict the age-specific distribution of total Testosterone (tT) levels among young men presenting to a single academic centre with uro-andrological complaints. Overall, tT levels from 2593 men aged 20-44 years were analyzed. Men were grouped into 'infertile men' and 'men with sexual dysfunction (SD)' according to their primary complaints. Data was also collected from 71 same-ethnicity age-comparable fertile controls. Linear regression fitted the relationship between tT and increasing age. Distribution of tT was determined for each 5-year age-group, both for the overall population and the subgroups. tT quantiles were reported for each sample sub-group and age-group. Of 2664 men, 1913 (71.81%) were classified as infertile, 680 (25.52%) with SD and 71 as fertile men (2.67%), respectively. tT levels depicted a reduction of 0.14 nmol/L per year between 20 and 44 years of age (p <
  0.001) within the overall study population. Significant reduction was also observed for the population stratified by urological complaints (all p <
  0.05). This is the first study to describe tT levels as a function of baseline clinical status in a large same-ethnicity cohort of young men, uniformly assessed using a standardized laboratory method.
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