Genetic association of diabetic retinopathy with long noncoding RNA

• Tác giả: Lun-Ching Chang, Hsiang-Wen Chien, Hung-Yu Lin, Shih-Chi Su, Kai Wang, Shun-Fa Yang, Yi-Sun Yang, Yen-Po Yao
• Ngôn ngữ: eng
• Ký hiệu phân loại: 809.008 History and description with respect to kinds of persons
• Thông tin xuất bản: United States : European journal of ophthalmology , 2025
• Bộ sưu tập: NCBI
• ID: 582045

Tóm tắt

 AIM: We attempted to test the influences of cyclin dependent kinase inhibitor 2B antisense RNA 1 (CDKN2B-AS1) gene polymorphisms on the susceptibility to Diabetic retinopathy (DR). METHODS: Five single-nucleotide polymorphisms (SNPs) of the CDKN2B-AS1 gene, rs564398, rs1333048, rs1537373, rs2151280, and rs8181047 were examined in 280 DR cases and 455 DR-free diabetic controls. RESULTS: Among these loci tested, we demonstrated that diabetic carriers of at least one polymorphic allele (G) of rs2151280 (AG and GG
  AOR, 1.613
  95% CI, 1.040-2.501
  CONCLUSION: Taken together, our findings implicate an impact of CDKN2B-AS1 gene polymorphisms on the progression of DR.