Macular thickness and visual acuity are characterized by a quadratic nonlinear relation in previously treated neovascular AMD eyes.

• Tác giả: Francesco Bandello, Enrico Borrelli, Giacomo Boscia, Matteo Fallico, Francesco Gelormini, Andrea Ghilardi, Marco Lupidi, Cesare Mariotti, Paola Marolo, Guglielmo Parisi, Michele Reibaldi, Federico Ricardi, SriniVas Sadda
• Ngôn ngữ: eng
• Thông tin xuất bản: United States : European journal of ophthalmology , 2025
• Bộ sưu tập: NCBI
• ID: 582085

Tóm tắt

PURPOSE: To assess the associations between visual acuity (VA) and retinal thickness in age-related macular degeneration (AMD) eyes treated with anti-vascular endothelial growth factor (VEGF) therapy. METHODS: Sixty-eight patients with neovascular AMD (68 eyes) undergoing anti-VEGF therapy with two years of follow-up imaging data after the initiation of treatment were retrospectively included. Linear and nonlinear regression analyses with curve fitting estimation were performed to explore the relationship between visual acuity and OCT-based parameters at the 3-month and 24-month follow-up visits. Regression analyses were also performed between visual acuity and the retinal thickness deviation which was calculated as the absolute value of the difference between measured and normative retinal thickness values. RESULTS: The VA was not associated with either foveal (R CONCLUSIONS: Although there was no linear relationship between retinal thickness and VA, a weak but statistically significant linear relationship could be observed when a retinal thickness deviation was considered. This suggests that deviation-based parameters may be beneficial for structure-function correlations in the context of anti-VEGF therapy for neovascular AMD.