HDAC2-Mediated METTL3 Delactylation Promotes DNA Damage Repair and Chemotherapy Resistance in Triple-Negative Breast Cancer.

• Tác giả: Guoan Chen, Sijie Chen, Jiangfeng Du, Xiaoniu He, Jian Li, Yu Li, Yuanpei Li, Qi Mei, Jianbo Song, Zhangrong Xie, Xia Yan
• Ngôn ngữ: eng
• Ký hiệu phân loại: 796.46 Trapeze work, rope climbing, tightrope walking
• Thông tin xuất bản: Germany : Advanced science (Weinheim, Baden-Wurttemberg, Germany) , 2025
• Bộ sưu tập: NCBI
• ID: 58225

Tóm tắt

The current treatment of triple-negative breast cancer (TNBC) is still primarily based on platinum-based chemotherapy. However, TNBC cells frequently develop resistance to platinum and experience relapse after drug withdrawal. It is crucial to specifically target and eliminate cisplatin-tolerant cells after platinum administration. Here, it is reported that upregulated N