Intestinal Gastrin/CCKBR Axis Protects against Type 2 Diabetes by Reducing Intestinal Glucose Absorption through the PI3K/Akt/eIF4B Signaling Pathway.

• Tác giả: Xiaodi Jia, Xiaoliang Jiang, Pedro A Jose, Wei Liu, Xing Liu, Xue Liu, Yunpeng Liu, Anxiong Long, Shuaibing Lu, Shiyun Sun, Qiang Wei, Xianxian Wu, Zhiwei Yang, Haizeng Zhang
• Ngôn ngữ: eng
• Thông tin xuất bản: Germany : Advanced science (Weinheim, Baden-Wurttemberg, Germany) , 2025
• Bộ sưu tập: NCBI
• ID: 58350

Tóm tắt

The Gastrin/CCKBR axis is essential for inhibiting intestinal sodium absorption, but its effects on intestinal glucose metabolism remain elusive. This study aims to determine the role of intestinal Gastrin/CCKBR on glucose absorption in the development of type 2 diabetes (T2D). Intestinal epithelial cell-specific Cckbr knockout mice and control wild-type mice are fed normal diet (ND, 10% fat) or high fat diet (HFD, 60% fat) to study the effect of intestinal Gastrin/CCKBR on blood glucose levels. Gastrin-SiO