PURPOSE: The primary purpose of this randomized, cross-sectional study was to determine whether operant conditioning of motor evoked torque (MEP METHODS: Thirty participants were block-randomized into one of three groups based on the participant's active motor threshold (100%, 120%, and 140%) to evaluate the effect of stimulus intensity. Participants received three blocks of conditioning trials (COND), where they trained to increase their MEP RESULTS: TKA participants were able to successfully increase their MEP CONCLUSION: Operant conditioning is a feasible approach for improving quadriceps corticospinal excitability following TKA. While any of the three stimulus intensities evaluated in this study may be used in future operant conditioning interventions, using a low or moderate stimulus intensity and 150 training trials are recommended to improve treatment efficiency and patient adherence. LEVEL OF EVIDENCE: Level II.