Gestationally administered RAS modulators reprogram endotoxic cardiovascular and inflammatory profiles in adult male offspring of preeclamptic rats.

• Tác giả: Salwa A Abuiessa, Hanan M El-Gowelli, Sahar M El-Gowilly, Mahmoud M El-Mas, Mai M Helmy
• Ngôn ngữ: eng
• Ký hiệu phân loại: 575.499 +Runners (Stolons)
• Thông tin xuất bản: Germany : Naunyn-Schmiedeberg's archives of pharmacology , 2025
• Bộ sưu tập: NCBI
• ID: 58971

Tóm tắt

Previous studies showed that preeclampsia (PE) amplifies cardiovascular dysfunction induced by endotoxemia in adult male, but not female, offspring. Here, we asked if such aggravated endotoxic insult could be nullified by modulators of the renin-angiotensin system (RAS). PE was induced by gestational administration of N