Plasma proteomics identifies proteins and pathways associated with incident depression in 46,165 adults.

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Tác giả: Yi-Lin Chen, Wei Cheng, Yue-Ting Deng, Jianfeng Feng, Yi-Jun Ge, Xiao-Yu He, Tianye Jia, Jujiao Kang, Wei-Shi Liu, Barbara J Sahakian, Lin-Bo Wang, Liu Yang, Yucheng T Yang, Jia You, Jin-Tai Yu, Wei Zhang, Yi Zhang, Xing-Ming Zhao, Yu-Jie Zhao

Ngôn ngữ: eng

Ký hiệu phân loại: 621.3125 Electrical, magnetic, optical, communications, computer engineering; electronics, lighting

Thông tin xuất bản: Netherlands : Science bulletin , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 593979

 Proteomic alterations preceding the onset of depression offer valuable insights into its development and potential interventions. Leveraging data from 46,165 UK Biobank participants and 2920 plasma proteins profiled at baseline, we conducted a longitudinal analysis with a median follow-up of 14.5 years to explore the relationship between plasma proteins and incident depression. Linear regression was then used to assess associations between depression-related proteins and brain structures, genetic factors, and stress-related events. Our analysis identified 157 proteins associated with incident depression (P <
 1.71 × 10
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