Early resilience and epigenetic ageing: Results from the prospective Young Finns Study with a 31-year follow-up.

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Tác giả: Binisha Hamal Mishra, Mika Kähönen, Liisa Keltikangas-Järvinen, Terho Lehtimäki, Leo-Pekka Lyytikäinen, Saara Marttila, Pashupati P Mishra, Nina Mononen, Olli Raitakari, Emma Raitoharju, Aino Saarinen

Ngôn ngữ: eng

Ký hiệu phân loại: 627.12 Rivers and streams

Thông tin xuất bản: England : Aging cell , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 59399

Evidence is accumulating on the connection of early adversities and harsh family environment with epigenetic ageing. We investigated whether early psychosocial resilience is associated with epigenetic ageing in adulthood. We used the population-based Young Finns data (n = 1593). Early psychosocial resilience was assessed in 1980-1989 across five broad domains: (1) index of psychological strength (self-esteem at home/in general/at school, perceived possibilities to influence at home, internal life control), (2) index of social satisfaction (perceived support from family/friends and life satisfaction), (3) index of leisure time activities (hobbies and physical fitness), (4) index of responsible health behaviors (infrequent smoking or alcohol consumption), and (5) index of school career (school grades and adaptation). Epigenetic ages were calculated for blood samples from 2011, and the analyses were performed with variables describing age deviation (AgeDev
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