Monoclonal Insulin Autoimmune Syndrome Successfully Treated With Plasma Cell Directed Therapy.

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Tác giả: Frida Bugge Askeland, Nils Bolstad, Ivar Følling, Hege M Frøen, Fredrik Schjesvold, Per Medbøe Thorsby, Geir E Tjønnfjord, Anne Cathrine Parelius Wammer

Ngôn ngữ: eng

Ký hiệu phân loại: 972.9505 *West Indies (Antilles) and Bermuda

Thông tin xuất bản: United States : Clinical lymphoma, myeloma & leukemia , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 59494

BACKGROUND: Monoclonal insulin autoimmune syndrome (IAS) is a very rare disease characterized by severe attacks of hypoglycemia caused by circulating anti-insulin antibodies produced by a B-cell clone, usually clonal plasma cells. METHOD: We present 2 female Norwegian patients with monoclonal IAS. The anti-insulin antibodies were quantified by immune precipitation and characterized using a 3-step manual in-house assay. Both patients received plasma cell directed therapy. RESULT: The first patient received plasma cell directed therapy for a time-limited period and achieved a sustained clinical remission without detectable anti-insulin antibodies. The second patient receives continuous plasma cell directed therapy and is in clinical remission with low values of detectable anti-insulin antibodies. CONCLUSION: Plasma cell directed therapy was effective and safe in our 2 cases of monoclonal IAS. We recommend considering plasma cell directed therapy for these patients.
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