Cell-Type-Specific Splicing of Transcription Regulators and

• Tác giả: Kaining Hu, Bowei Kang, Aileen Kauffman, Xiangbin Ruan, Elizabeth Tseng, Runwei Yang, Yalan Yang, Xiaochang Zhang, Rong Zhong
• Ngôn ngữ: eng
• Ký hiệu phân loại: 491.89 *Polabian
• Thông tin xuất bản: United States : The Journal of neuroscience : the official journal of the Society for Neuroscience , 2025
• Bộ sưu tập: NCBI
• ID: 59568

Tóm tắt

How master splicing regulators cross talk with each other and to what extent transcription regulators are differentially spliced remain unclear in the developing brain. Here, cell-type-specific RNA-Seq analyses of the developing neocortex uncover variable expression of the Rbfox1/2/3 genes and enriched alternative splicing events in transcription regulators, altering protein isoforms or inducing nonsense-mediated mRNA decay. Transient expression of Rbfox proteins in radial glial progenitors induces neuronal splicing events preferentially in transcription regulators such as