Visual read of [F-18]florquinitau PET that includes and extends beyond the mesial temporal lobe is associated with increased plasma pTau217 and cognitive decline in a cohort that is enriched with risk for Alzheimer's disease.

• Tác giả: Sanjay Asthana, Melissa Bahr, Barbara B Bendlin, Tobey J Betthauser, Nathaniel A Chin, Bradley T Christian, Lindsay R Clark, Karly A Cody, Laura Eisenmenger, Sterling C Johnson, Erin M Jonaitis, Rebecca E Langhough, Olivia Mandel, Ozioma C Okonkwo, Ramiro Eduardo Rea Reyes, Rachael E Wilson, Madilynn Wintlend, Matt Zammit, Henrik Zetterberg
• Ngôn ngữ: eng
• Ký hiệu phân loại: 012 Bibliographies and catalogs of individuals
• Thông tin xuất bản: United States : Alzheimer's & dementia : the journal of the Alzheimer's Association , 2025
• Bộ sưu tập: NCBI
• ID: 595700

Tóm tắt

INTRODUCTION: Patterns of signal from tau positron emission tomography (tau-PET) confined to the medial temporal lobe (MTL) or extended into the neocortex may be relevant for Alzheimer's disease (AD) research if they are linked to differential biomarker levels and cognitive decline. METHODS: Visual assessment of Tau-PET [F-18]florquinitau (FQT) exams from 728 initially non-demented older adults yielded four uptake groups: tau-negative (T-), MTL-only (T+ RESULTS: T+ DISCUSSION: The T+ HIGHLIGHTS: Visual assessments of Tau-PET FQT revealed four distinct uptake groups: tau-negative (T-), MTL-only (T+