Assessing the causal association between celiac disease and autism spectrum disorder: A two-sample Mendelian randomization approach.

• Tác giả: Abiodun Fatoba, Claire Simpson
• Ngôn ngữ: eng
• Ký hiệu phân loại: 616.8527 Diseases of nervous system and mental disorders
• Thông tin xuất bản: United States : Autism research : official journal of the International Society for Autism Research , 2025
• Bộ sưu tập: NCBI
• ID: 59729

Tóm tắt

 The association between celiac disease (CD) and autism spectrum disorder (ASD) remains inconclusive. Reports from different observational studies have become controversial, necessitating exploration of the causal relationship between CD and ASD. To assess true causality, this study used a two-sample Mendelian randomization (MR) analysis to determine the causal association between CD and ASD. Summary-level data from a genome-wide association study (GWAS) of the European population were used to select instrument variables (IVs) at genome-wide significance (p <
  5 × 10