Dodecafluoropentane improves neuro-behavioral outcomes and return of spontaneous circulation rate in a swine model of cardiac arrest.

• Tác giả: Torben K Becker, Robert J Cueto, Ian T Griffin, Firas H Kobeissy, Gagan Midathala, Jacob Milling, Travis W Murphy, Muna Oli, Justin Sauter, Bruce Spiess, J Adrian Tyndall, Kevin K W Wang, Jiepei Zhu
• Ngôn ngữ: eng
• Thông tin xuất bản: England : Brain injury , 2025
• Bộ sưu tập: NCBI
• ID: 597619

Tóm tắt

INTRODUCTION: Dodecafluoropentane emulsion (DDFPe) administration has previously demonstrated improved gas exchange in single-organ perfusion models. This could translate to prevention of brain injury in cardiac arrest. METHODS: We induced cardiac arrest in 12 pigs, performing CPR after 5-minute downtime. Pigs were randomly assigned to DDFPe ( RESULTS: One placebo and four DDFPe pigs survived the 96-hour observation period. The odds ratio for ROSC was 7.2 ( CONCLUSION: The findings of this novel study provide a proof of concept and early signal toward efficacy of intravenous DDFPe in cardiac arrest. The trend toward improved ROSC and functional survival may reflect improved microcirculatory gas exchange in DDFPe animals. Improving gas exchange in brain microcirculation during resuscitation from cardiac arrest may provide a significant therapeutic benefit.