Population pharmacokinetics of caspofungin in critically ill patients receiving extracorporeal membrane oxygenation-an ASAP ECMO study.

• Tác giả: Mohd H Abdul-Aziz, Vesa Cheng, Amanda Corley, Arne Diehl, John F Fraser, Eileen Gilder, Bianca Levkovich, Xin Liu, Shay McGuinness, Jenny Ordonez, Rachael Parke, Vincent Pellegrino, Jason A Roberts, Kiran Shekar, Steven C Wallis
• Ngôn ngữ: eng
• Ký hiệu phân loại: 003.0285 Systems
• Thông tin xuất bản: United States : Antimicrobial agents and chemotherapy , 2025
• Bộ sưu tập: NCBI
• ID: 59892

Tóm tắt

This study aimed to describe the population pharmacokinetics of caspofungin in critically ill patients receiving extracorporeal membrane oxygenation (ECMO) and to identify dosing regimens with a high likelihood of achieving effective exposures. Serial blood samples were collected over a single-dosing interval during ECMO. Total plasma concentrations were measured by a validated chromatographic assay. A population pharmacokinetic model was built and Monte Carlo dosing simulations were performed using Monolix. The probability of target attainment (PTA) and fractional target attainment (FTA) rates were simulated for various caspofungin dosing regimens against