Population pharmacokinetics of piperacillin-tazobactam in the plasma and cerebrospinal fluid of critically ill patients.

• Tác giả: Menino Osbert Cotta, Aaron J Heffernan, Gavin M Joynt, Nilesh Kumta, Jeffrey Lipman, Xin Liu, Amelia Livermore, Suzanne Parker, Jason A Roberts, Therese Starr, Steven Wallis, Wai Tat Wong
• Ngôn ngữ: eng
• Thông tin xuất bản: United States : Antimicrobial agents and chemotherapy , 2025
• Bộ sưu tập: NCBI
• ID: 59907

Tóm tắt

Ventriculitis in neurocritical care patients leads to significant morbidity and mortality. Antibiotic dose optimization targeting pharmacokinetic/pharmacodynamic (PK/PD) exposures associated with improved bacterial killing may improve therapeutic outcomes. We sought to develop and apply a population PK model in infected critically ill patients to determine optimal piperacillin-tazobactam (PTZ) dosing regimens to achieve target cerebrospinal fluid (CSF) exposures. Neurosurgical patients with external ventricular drains and receiving PTZ treatment were recruited and had plasma and CSF samples collected and assayed. A population PK model was developed using plasma and CSF piperacillin and tazobactam concentrations. Eight patients were recruited. Median age was 59 years, median weight was 70 kg, and five patients were female. The median creatinine clearance was 84 mL/min/1.73 m