The Accreditation Council for Pharmacy Education has developed the Accreditation Standards and Key Elements for the Professional Program in Pharmacy Leading to the PharmD Degree (Standards 2025), effective July 1, 2025. This article describes the processes used to revise the accreditation standards and key elements, as well as changes made from Standards 2016 to Standards 2025. Communities of interest were invited to provide written comments via email or participate in a web-based survey. Standards 2025 introduces significant changes based on stakeholder feedback, including a reduction from 25 standards to 7.