Dermal penetration of 2-phenoxyethanol in humans: in vivo metabolism and toxicokinetics.

• Tác giả: Michael Bader, Elisabeth Eckert, Thomas Göen, Julia Hiller, Thomas Jäger, Edgar Leibold
• Ngôn ngữ: eng
• Ký hiệu phân loại: 729.6 Decoration in veneer and incrustation
• Thông tin xuất bản: Germany : Archives of toxicology , 2025
• Bộ sưu tập: NCBI
• ID: 60096

Tóm tắt

2-Phenoxyethanol (PhE) is an amphiphilic organic compound frequently used as a broad-spectrum preservative in cosmetic products and other consumer goods. PhE is also used as a biocidal component in occupational settings. A previous volunteer study by our working group following oral exposure to PhE showed that PhE is almost completely taken up into the human body followed by an extensive metabolization and fast urinary elimination. However, with respect to the importance of transdermal uptake, we now conducted another volunteer study applying dermal PhE exposure: five volunteers were dermally exposed with 0.4 mg/kg body weight of PhE each on a specified 800 cm