PURPOSE: To compare the parameters and indices of a novel swept-source optical coherence tomography device (SS-OCT, ANTERION) with those of a rotating Scheimpflug camera (RSC)-based tomograph (Pentacam) in normal and keratoconic (KC) eyes. METHODS: This prospective, monocentric, cross-sectional study included individuals with unoperated normal and KC eyes, selecting one eye per subject. Ectasia-specific parameters analysed with the SS-OCT were difference in mean keratometry (K RESULTS: This study included 117 individuals with healthy eyes and 335 eyes with KC. The indices with the highest diagnostic discriminatory ability between the two cohorts were SCORE, difference of K CONCLUSION: The diagnostic capabilities for both devices were found to be comparable. KC classification using SS-OCT can be independently based on the anterior surface, posterior surface and corneal thickness.