Efferocytosis: The Janus-Faced Gatekeeper of Aging and Tumor Fate.

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Tác giả: Yuhao Ba, Jingqi Chen, Quan Chen, Xinwei Han, Yan Li, Shutong Liu, Zaoqu Liu, Peng Luo, Teng Pan, Yuqing Ren, Siyuan Weng, Hui Xu, Yuyuan Zhang, Zhaokai Zhou, Anning Zuo

Ngôn ngữ: eng

Ký hiệu phân loại: 594.38 *Pulmonata

Thông tin xuất bản: England : Aging cell , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 60152

From embryogenesis to aging, billions of cells perish daily in mammals. The multistep process by which phagocytes engulf these deceased cells without eliciting an inflammatory response is called efferocytosis. Despite significant insights into the fundamental mechanisms of efferocytosis, its implications in disorders such as aging and cancer remain elusive. Upon summarizing and analyzing existing studies on efferocytosis, it becomes evident that efferocytosis is our friend in resolving inflammation, yet it transforms into our foe by facilitating tumor development and metastasis. This review illuminates recent discoveries regarding the emerging mechanisms of efferocytosis in clearing apoptotic cells, explores its connections with aging, examines its influence on tumor development and metastasis, and identifies the regulatory factors of efferocytosis within the tumor microenvironment. A comprehensive understanding of these efferocytosis facets offers insights into crucial physiological and pathophysiological processes, paving the way for innovative therapeutic approaches to combat aging and cancer.
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