Amyloid beta (Aβ) fibrillation kinetics and its impact on membrane polarity.

• Tác giả: Arun Ajaikumar, Yukihiro Okamoto, Keishi Suga, Hiroshi Umakoshi, Nozomi Morishita Watanabe
• Ngôn ngữ: eng
• Ký hiệu phân loại: 618.0835 Other branches of medicine Gynecology and obstetrics
• Thông tin xuất bản: United States : Journal of bioenergetics and biomembranes , 2025
• Bộ sưu tập: NCBI
• ID: 60233

Tóm tắt

Fibrillation of the amyloid beta (Aβ) peptide has often been associated with neurodegenerative pathologies such as Alzheimer's disease. In this study we examined the influence of several potential compositions of the lipid membrane on Aβ fibrillation by using liposomes as a basic model membrane. Firstly, it was revealed that Aβ fibrillation kinetics were enhanced and had the potential to occur at a faster rate on more fluid membranes compared to solid membranes. Next, the extent of fibril-related damage to membranes was examined with analysis of membrane polarity via the steady-state emission spectra of 6-dodecanoyl-2-dimethylaminonaphthalene (Laurdan). It was revealed that there was slight hydration behavior of the membrane during the lag phase (t