Selection of LRP1 ligand phage-displayed single domain antibody that transmigrates BBB.

• Tác giả: Frank Camacho Casanova, Pablo Ignacio Castro Henriquez, Maria A Contreras Vera, Nery A Jara Mendoza, Bryan A Mangui Catota, Viana Manrique-Suárez, Rafael Maura Pérez, Fátima Reyes López, Oliberto Sánchez Ramos, Roberto Toledo Alonso
• Ngôn ngữ: eng
• Thông tin xuất bản: England : Journal of drug targeting , 2025
• Bộ sưu tập: NCBI
• ID: 603574

Tóm tắt

Effective drug delivery to the central nervous system (CNS) remains a challenge due to the blood-brain barrier (BBB). Macromolecules such as proteins and peptides are unable to cross BBB and have poor therapeutic efficacy due to little or no drug distribution. A promising alternative is the conjugation of a drug to a shuttle molecule that can reach the CNS via receptor-mediated transcytosis (RMT). Several receptors have been described for RMT, such as low-density lipoprotein receptor-related protein 1 (LRP1). We used phage display technology combined with an