Clec12a controls colitis by tempering inflammation and restricting expansion of specific commensals.

• Tác giả: Kaylyn M Bauer, Rickesha Bell, Tyson R Chiaro, Morgan Greenewood, Jennifer H Hill, Taylor Jackson, Kendra A Klag, Michaela Murphy, Morgan C Nelson, Ryan M O'Connell, Kyla S Ost, June L Round, Emmanuel Stephen-Victor, Warren Voth, Allison M Weis, W Zac Stephens
• Ngôn ngữ: eng
• Thông tin xuất bản: United States : Cell host & microbe , 2025
• Bộ sưu tập: NCBI
• ID: 60359

Tóm tắt

Microbiota composition regulates colitis severity, yet the innate immune mechanisms that control commensal communities and prevent disease remain unclear. We show that the innate immune receptor, Clec12a, impacts colitis severity by regulating microbiota composition. Transplantation of microbiota from a Clec12a