Nonclinical and clinical characterization of the absorption, metabolism, and excretion of islatravir.

• Tác giả: Kerry L Fillgrove, Marian Iwamoto, Yuexia Liang, Wen Liu, Yang Liu, Bing Lu, Catherine Z Matthews, Randolph P Matthews, Munjal Patel, Rosa I Sanchez, S Aubrey Stoch
• Ngôn ngữ: eng
• Ký hiệu phân loại: 920.71 Men
• Thông tin xuất bản: United States : Antimicrobial agents and chemotherapy , 2025
• Bộ sưu tập: NCBI
• ID: 60565

Tóm tắt

The development of new and improved antiretroviral therapies that allow for alternative dosing schedules is needed for people living with HIV-1. Islatravir is a deoxyadenosine analog in development for the treatment of HIV-1 that suppresses HIV-1 replication via multiple mechanisms of action, including reverse transcriptase translocation inhibition and delayed chain termination. Islatravir is differentiated from other HIV-1 antiretrovirals by its high potency, long