Efficacy and safety of home-based transcranial direct current stimulation as adjunct treatment for cognitive improvement in major depressive disorder: A double-blind, randomized, multi-site clinical trial.

• Tác giả: J E Ahn, Ji Hyun Baek, T H Ha, H K Ihm, Y Jang, J Kim, S S Kwon, C W Lee, D Lee, J Lee, Y I Lee, S-E Lim, Woojae Myung, H Y Park, K Park, Y S Park, I-Y Yoon, H Yu
• Ngôn ngữ: eng
• Ký hiệu phân loại: 920.71 Men
• Thông tin xuất bản: England : European psychiatry : the journal of the Association of European Psychiatrists , 2025
• Bộ sưu tập: NCBI
• ID: 60587

Tóm tắt

 BACKGROUND: Transcranial direct current stimulation (tDCS) is a promising treatment for major depressive disorder (MDD). This study evaluated its antidepressant and cognitive effects as a safe, effective, home-based therapy for MDD. METHODS: This double-blind, sham-controlled, randomized trial divided participants into low-intensity (1 mA, RESULTS: In the tDCS study, of 141 participants (102 [72.3%] women
  mean age 35.7 years, standard deviation 12.7), 95 completed the trial. Mean changes in the total accuracy scores from baseline to week 6 were compared across the three groups using an CONCLUSIONS: Home-based tDCS for MDD demonstrated no evidence of effectiveness but was safe and well-tolerated. Further research is needed to address the technical limitations, evaluate broader cognitive functions, and extend durations to evaluate its therapeutic potential.