Molecular docking to investigate HLA-associated idiosyncratic drug reactions.

• Tác giả: Volker M Lauschke, Kejun Li, Yitian Zhou
• Ngôn ngữ: eng
• Ký hiệu phân loại: 371.217 Entrance requirements
• Thông tin xuất bản: England : Drug metabolism reviews , 2025
• Bộ sưu tập: NCBI
• ID: 60600

Tóm tắt

Idiosyncratic drug reactions (IDRs) pose severe threats to patient health. Unlike conventionally dose-dependent side effects, they are unpredictable and more frequently manifest as life-threatening conditions, such as severe cutaneous adverse reactions (SCARs) and drug-induced liver injury (DILI). Some HLA alleles, such as