Fiber- and acetate-mediated modulation of MHC-II expression on intestinal epithelium protects from Clostridioides difficile infection.

• Tác giả: Bishan Bhattarai, Siyan Cao, Marco Colonna, Sarah de Oliveira, José L Fachi, Mariane Font Fernandes, Susan Gilfillan, Krzysztof L Hyrc, Brian T Layden, Xiuli Liu, Silvia Penati, Pollyana Ribeiro Castro, Patrick Fernandes Rodrigues, Tihana Trsan, Marco Aurélio R Vinolo
• Ngôn ngữ: eng
• Thông tin xuất bản: United States : Cell host & microbe , 2025
• Bộ sưu tập: NCBI
• ID: 60792

Tóm tắt

Here, we explore the relationship between dietary fibers, colonic epithelium major histocompatibility complex class II (MHC-II) expression, and immune cell interactions in regulating susceptibility to Clostridioides difficile infection (CDI). We find that a low-fiber diet increases MHC-II expression in the colonic epithelium, which, in turn, worsens CDI by promoting the development of pathogenic CD4