Rapid, inexpensive multiplex pathogen detection using resequencing microarrays.

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Tác giả: John Chiang, Filip Crnogorac, Xun Ding, Jie Duan, Samantha Dung, John Duque, Jeremy Edwards, Kendall Hoff, Ju-Yu Lin, Xing Liang Liu, Glenn McGall, Su Yu, Wei Zhou

Ngôn ngữ: eng

Ký hiệu phân loại: 920.71 Men

Thông tin xuất bản: Netherlands : Journal of virological methods , 2025

Mô tả vật lý:

Bộ sưu tập: NCBI

ID: 60818

Humanity faces an ongoing battle at the microscopic level to identify, contain, and treat outbreaks of numerous pathogens each year. Global genomic surveillance is the first step in monitoring outbreaks, but high-throughput methods are expensive and time-consuming. To solve this problem, we designed and manufactured a resequencing microarray capable of identifying 35 viral pathogens, 21 pathogenic bacteria, 16 antibiotic resistance genes, and 6 controls. We then developed an assay using these microarrays for the rapid detection of SARS-CoV-2, influenza A, and influenza B. Here, we present the clinical validation data for this test. The assay requires less than two hours to complete and has high-sensitivity, with limits of detection of 125 copies per mL for SARS-CoV-2, 0.01-0.05 TCID
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