PURPOSE: Our study was intended to verify whether the trend of AMI mortality throughout the different months of the year may have recently changed in the US due to the coronavirus disease 2019 (COVID-19) pandemic and climate changes. METHODS: We examined monthly mortality trends for acute myocardial infarction (AMI) in the U.S. from 2018 to 2022 by conducting an electronic search of the latest version of the CDC Wonder (Wide-Ranging, Online Data for Epidemiologic Research) online database. We calculated and analyzed the mean and standard deviation (SD) of cumulative AMI deaths each month from 2018 to 2022. RESULTS: We observed a notable seasonal pattern, with mortality peaking in December and January and dropping from June to September. AMI-related deaths were significantly higher in January compared to other months, except December, with no significant difference between December and January (P = .868). The lowest mortality rates were observed in summer, with a marked decline between March and September. Statistically, the monthly variation in mean AMI deaths was significant (ANOVA, f = 13.1, P <
.001). CONCLUSION: Healthcare systems should allocate resources effectively during winter to manage this seasonal burden.