Variants and vaccines impact nasal immunity over three waves of SARS-CoV-2.

• Tác giả: Chelsea Asare, John T Bates, Benjamin C Billingsley, Joshua D Bromley, Yesenia T Davis, Neha S Dhaliwal, Gill Diamond, Paul Dotherow, Riley S Drake, I J Frame, Michael R Garrett, Micayla George, Sarah C Glover, Yanglin Guo, Jessie Harvey, Bruce H Horwitz, Samira Ibrahim, Tasneem Jivanjee, Samuel W Kazer, Kyle Kimler, Sai K Kota, Hannah Laird, Jonathan J Lyons, Vincent N Miao, Andrew W Navia, Jose Ordovas-Montanes, Anna H Owings, Adam Parker, Yilianys Pride, D Ashley Robinson, Tanya O Robinson, Michal Senitko, Alex K Shalek, Ying Tang, Spurthi Tarugu, Jaclyn M L Walsh, T Grant Wichman, Carly G K Ziegler
• Ngôn ngữ: eng
• Thông tin xuất bản: United States : Nature immunology , 2025
• Bộ sưu tập: NCBI
• ID: 60896

Tóm tắt

Viral variant and host vaccination status impact infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), yet how these factors shift cellular responses in the human nasal mucosa remains uncharacterized. We performed single-cell RNA sequencing (scRNA-seq) on nasopharyngeal swabs from vaccinated and unvaccinated adults with acute Delta and Omicron SARS-CoV-2 infections and integrated with data from acute infections with ancestral SARS-CoV-2. Patients with Delta and Omicron exhibited greater similarity in nasal cell composition driven by myeloid, T cell and SARS-CoV-2