INTRODUCTION: This study aimed to compare changes in retinal oxygen saturation 1 month after femtosecond-assisted laser in situ keratomileusis (FS-LASIK) in Chinese adults with myopia using retinal oximetry. METHODS: In this prospective, observational, single-center cohort study, Chinese adults aged 18-45 years with myopia were categorized into four groups according to spherical equivalent (SE), with 66 eyes characterized as low myopia (LM -3.00D <
SE ≤ -0.50D), 68 eyes as moderate myopia (MM -6.00D <
SE ≤ -3.00D), 68 eyes as high myopia (HM -9.00D <
SE ≤ -6.00D), and 65 eyes as super-high myopia (SHM: SE ≤ -9.00D). The following were measured before and 1 month after FS-LASIK: SE, intraocular pressure (IOP), average keratometry (Km), and axial length (AL). Other ocular biological parameters included retinal arterial oxygen saturation (SaO RESULTS: Of the 267 participants, 63.30% were female and 36.70% were male. The mean SE, AL, SaO CONCLUSION: Ruling out the influence of refractive error, SaO