In vivo calcium extrusion from accumbal astrocytes reduces anxiety-like behaviors but increases compulsive-like responses and compulsive ethanol drinking in mice.

• Tác giả: Robert Bruce, Doo-Sup Choi, Hesham Essa, Humza Haroon, Lee Peyton, Anthony Umpierre, Long-Jun Wu
• Ngôn ngữ: eng
• Ký hiệu phân loại: 305.568 +Alienated and excluded classes
• Thông tin xuất bản: England : Neuropharmacology , 2025
• Bộ sưu tập: NCBI
• ID: 60983

Tóm tắt

The ventral striatum is crucially involved in reward processing. The present study investigates the behavioral effects of astrocyte-specific calcium extrusion virus "CalEx" on perseverative responses in the operant five-choice serial reaction time task and ethanol-conditioned place preference. Mice were injected with CalEx via the GfaABC