BAFF Blockade Attenuates B Cell MALT Formation in Conditional Nlrc5-Deficient Mice With Helicobacter felis Infection.

• Tác giả: Michelle Chonwerawong, Jack Emery, Richard L Ferrero, Shambel Araya Haile, Yuqi He, Paul J Hertzog, Lena H M Le, Zoe Lee, Dana J Philpott, Pascal Schneider, Dongmei Tong, Georgie Wray-McCann, Le Ying
• Ngôn ngữ: eng
• Ký hiệu phân loại: 615.8043 Specific therapies and kinds of therapies
• Thông tin xuất bản: Germany : European journal of immunology , 2025
• Bộ sưu tập: NCBI
• ID: 614599

Tóm tắt

Helicobacter infection is a key cause of gastric B cell mucosa-associated lymphoid tissue (MALT) lymphoma. This study examined the role of B cell-activating factor (BAFF), a major driver of B cell proliferation and many B cell disorders, in this malignancy using a model in which conditional knockout mice for NOD-like receptor family CARD domain-containing 5 (Nlrc5) are infected with Helicobacter felis. Gastric BAFF production was significantly increased in H. felis-infected Nlrc5