Laser-structuring techniques like Direct Laser Interference Patterning show great potential for optimizing electrodes for water electrolysis. Therefore, a systematic experimental study is performed to analyze the influence of the spatial period and the aspect ratio between spatial period and structure depth on the electrode performance for pure Ni electrodes. Using a statistical design of experiments approach, it is found that the spatial distance between the laser-structures is the decisive processing parameter for the improvement of the electrode performance. Thus, the electrochemically active surface area could be increased by a factor of 12 compared to a nonstructured electrode. For oxygen evolution reaction, a significantly lower onset potential and overpotential (≈ -164 mV at 100 mA cm