The catalytic depolymerization of lignin has long been challenged by the limited catalytic mass transfer and the complexity of its polymer structure. In this work, a series of hierarchical MFI nanosheet catalysts (named AL-MFI, M-BKC-MFI, M(metal)-AL-MFI and M(metal)-BKC-MFI, respectively) using biomass (lignin and lignin biochar) as a template were designed to realize the oxidative depolymerization of lignin and its derivatives efficiently and stably. The Zn element in the M-AL-MFI and M-BKC-MFI compensated for the acidity, while Ce could stimulate the production of O